Structure of PDB 5l7h Chain A

Receptor sequence
>5l7hA (length=249) Species: 9606 (Homo sapiens) [Search protein sequence]
YFSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQVVKWA
KVLPGFKNLPLEDQITLIQYSWMSLLSFALSWRSYKHTNSQFLYFAPDLV
FNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKD
GLKSQAAFEEMRTNYIKELRKMVTKSPNSGQSWQRFYQLTKLLDSMHDLV
SDLLEFCFYTFRESHALKVEFPAMLVEIISDQLPKVESGNAKPLYFHRK
3D structure
PDB5l7h Structure-Based Drug Design of Mineralocorticoid Receptor Antagonists to Explore Oxosteroid Receptor Selectivity.
ChainA
Resolution1.84 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V781 K785 L795 I799 A958 M959 E962 V47 K51 L61 I65 A223 M224 E227
BS02 6QG A L769 N770 L772 A773 Q776 W806 M807 L810 S811 L814 M845 F941 C942 L35 N36 L38 A39 Q42 W72 M73 L76 S77 L80 M111 F206 C207 MOAD: Ki=50nM
PDBbind-CN: -logKd/Ki=7.30,Ki=50nM
External links
PDB RCSB:5l7h, PDBe:5l7h, PDBj:5l7h
PDBsum5l7h
PubMed27897427
UniProtP08235|MCR_HUMAN Mineralocorticoid receptor (Gene Name=NR3C2)

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