Structure of PDB 5l7g Chain A

Receptor sequence
>5l7gA (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
SPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQVVKWAKV
LPGFKNLPLEDQITLIQYSWMSLLSFALSWRSYKHTNSQFLYFAPDLVFN
EEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGL
KSQAAFEEMRTNYIKELRKMVTKSPNSGQSWQRFYQLTKLLDSMHDLVSD
LLEFCFYTFRESHALKVEFPAMLVEIISDQLPKVESGNAKPLYFHRK
3D structure
PDB5l7g Structure-Based Drug Design of Mineralocorticoid Receptor Antagonists to Explore Oxosteroid Receptor Selectivity.
ChainA
Resolution2.01 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V781 K785 L795 I799 I802 A958 M959 E962 V45 K49 L59 I63 I66 A221 M222 E225
BS02 6QE A L769 N770 L772 A773 Q776 W806 M807 L810 S811 L814 F829 M845 C849 M852 L938 F941 C942 L33 N34 L36 A37 Q40 W70 M71 L74 S75 L78 F93 M109 C113 M116 L201 F204 C205 MOAD: Ki=16nM
PDBbind-CN: -logKd/Ki=7.80,Ki=16nM
External links
PDB RCSB:5l7g, PDBe:5l7g, PDBj:5l7g
PDBsum5l7g
PubMed27897427
UniProtP08235|MCR_HUMAN Mineralocorticoid receptor (Gene Name=NR3C2)

[Back to BioLiP]