Structure of PDB 5l7e Chain A

Receptor sequence
>5l7eA (length=243) Species: 9606 (Homo sapiens) [Search protein sequence]
SPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQVVKWAKV
LPGFKNLPLEDQITLIQYSWMSLLSFALSWRSYKHTNSQFLYFAPDLVFN
EEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGL
KSQAAFEEMRTNYIKELRKMVTKSQSWQRFYQLTKLLDSMHDLVSDLLEF
CFYTFRESHALKVEFPAMLVEIISDQLPKVESGNAKPLYFHRK
3D structure
PDB5l7e Structure-Based Drug Design of Mineralocorticoid Receptor Antagonists to Explore Oxosteroid Receptor Selectivity.
ChainA
Resolution1.86 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V781 K785 L795 I799 A958 M959 E962 V45 K49 L59 I63 A217 M218 E221
BS02 6Q0 A L769 N770 L772 A773 Q776 W806 M807 L810 S811 M845 M852 F941 C942 L33 N34 L36 A37 Q40 W70 M71 L74 S75 M109 M116 F200 C201 MOAD: Ki=0.25uM
PDBbind-CN: -logKd/Ki=6.60,Ki=0.25uM
External links
PDB RCSB:5l7e, PDBe:5l7e, PDBj:5l7e
PDBsum5l7e
PubMed27897427
UniProtP08235|MCR_HUMAN Mineralocorticoid receptor (Gene Name=NR3C2)

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