Structure of PDB 5l6p Chain A

Receptor sequence
>5l6pA (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
CVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLS
EASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFT
VIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSR
FLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEV
MSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNL
RPKFSQIVNTLDKLIRNPASLKVI
3D structure
PDB5l6p Development of Specific, Irreversible Inhibitors for a Receptor Tyrosine Kinase EphB3.
ChainA
Resolution2.26 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D758 A760 R762 N763 D776 K799
Catalytic site (residue number reindexed from 1) D127 A129 R131 N132 D145 K168
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6P8 A I639 A663 K665 T711 M714 C717 L765 I8 A32 K34 T80 M83 C86 L134 PDBbind-CN: -logKd/Ki=7.26,IC50=55nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5l6p, PDBe:5l6p, PDBj:5l6p
PDBsum5l6p
PubMed27478969
UniProtP54753|EPHB3_HUMAN Ephrin type-B receptor 3 (Gene Name=EPHB3)

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