Structure of PDB 5l6o Chain A

Receptor sequence
>5l6oA (length=267) Species: 9606 (Homo sapiens) [Search protein sequence]
CVKIEEVIGAGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEAS
IMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQ
LVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLEDDPS
DPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERP
YWDMSNQDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQI
VNTLDKLIRNPASLKVI
3D structure
PDB5l6o Development of Specific, Irreversible Inhibitors for a Receptor Tyrosine Kinase EphB3.
ChainA
Resolution1.88 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D758 A760 R762 N763 D776 K799
Catalytic site (residue number reindexed from 1) D124 A126 R128 N129 D142 K161
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6P6 A A663 M686 I709 T711 F713 M714 C717 L765 A29 M52 I75 T77 F79 M80 C83 L131 PDBbind-CN: -logKd/Ki=8.22,IC50=6nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5l6o, PDBe:5l6o, PDBj:5l6o
PDBsum5l6o
PubMed27478969
UniProtP54753|EPHB3_HUMAN Ephrin type-B receptor 3 (Gene Name=EPHB3)

[Back to BioLiP]