Structure of PDB 5l5x Chain A

Receptor sequence
>5l5xA (length=250) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
MTDRYSFSLTTFSPSGKLGQIDYALTAVKQGVTSLGIKATNGVVIATEKK
SSSPLAMSETLSKVSLLTPDIGAVYSGMGPDYRVLVDKSRKVAHTSYKRI
YGEYPPTKLLVSEVAKIMQEATQSGGVRPFGVSLLIAGHDEFNGFSLYQV
DPSGSYFPWKATAIGKGSVAAKTFLEKRWNDELELEDAIHIALLTLKESV
EGEFNGDTIELAIIGDENPDLLGYTGIPTDKGPRFRKLTSQEINDRLEAL
3D structure
PDB5l5x A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit beta 5i.
ChainA
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E48 K50 K63 G77 K166 E203 N205
Catalytic site (residue number reindexed from 1) E48 K50 K63 G77 K166 E203 N205
Enzyme Commision number 3.4.25.1: proteasome endopeptidase complex.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A M118 P129 F130 P152 M118 P129 F130 P152
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0010499 proteasomal ubiquitin-independent protein catabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051603 proteolysis involved in protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005839 proteasome core complex
GO:0019773 proteasome core complex, alpha-subunit complex
GO:0034515 proteasome storage granule

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5l5x, PDBe:5l5x, PDBj:5l5x
PDBsum5l5x
PubMed27789522
UniProtP23639|PSA2_YEAST Proteasome subunit alpha type-2 (Gene Name=PRE8)

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