Structure of PDB 5l44 Chain A

Receptor sequence
>5l44A (length=662) Species: 592016 (Astrosporangium hypotensionis K-26) [Search protein sequence]
ENPFFAPSALPYGLPPFAEIREEHYVPAFERGMAEQLAEVEAIAGDTEAP
TFDNTVAALERSGQVLTRVSAVFFNQSSSDTNPTVQEIQKQIIPKLTQHG
DAIHLNRPLFARIKQISPDGLDAEQAWLLERYVTDFVRAGAELGAGDQER
LKALNEELSTLSTRFEQNLLAHTNASAVIVDDVAQLDGLSDDSVKAAAET
AKSRGLPGKYVIPLVLPTGQPGLAELTDRALRERIHRASIQRGVPDNEEL
IVRIATLRAERAKLLGYPTHAAYVVADQTAPTTEAVTEMLGKLTPPAVAN
AHREADELREQAGHDLEPWDWSFYAEKVLKERYAIDGRQMRPYFELDRVL
RDGVFHAATLLYGITFTERPDLVGYHPDVRVFEVFNEDGSQLGLFLGDYY
ARPSKRGGAWMNSLVKQSTLEGTRPVVVNNLNIAKPPAGEPTLMTFEEVN
TMFHEFGHALHGLFSEVHYPRFSGTAVPRDFVEYPSQVNEMWAVWPSVLA
NYARHWQTGDPMPKDLLDRMLKSQKYNQGYKTVEYLAATLLDWSWHTFQT
PPENALTFEHEALTTAGVDLKLVPPRYRSTYFAHIWSSGYSAGYYSYIWS
EVLDADTVDWFHENGGLLRENGDTFRQKLLSKGGSVDPMTAFQSFRGRTP
RIEPLLDRRGLL
3D structure
PDB5l44 Crystal structure of a peptidyl-dipeptidase K-26-DCP from Actinomycete in complex with its natural inhibitor.
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H463 E464 H467 Y606
Catalytic site (residue number reindexed from 1) H454 E455 H458 Y597
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H463 H467 E492 H454 H458 E483
BS02 MG A D524 D527 D515 D518
BS03 K26 A R415 A418 W419 M420 H463 E464 H467 T484 R488 E492 H593 S597 Y599 Y606 R406 A409 W410 M411 H454 E455 H458 T475 R479 E483 H584 S588 Y590 Y597 PDBbind-CN: -logKd/Ki=4.40,IC50=40uM
Gene Ontology
Molecular Function
GO:0004180 carboxypeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005829 cytosol
GO:0030288 outer membrane-bounded periplasmic space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5l44, PDBe:5l44, PDBj:5l44
PDBsum5l44
PubMed27754586
UniProtA0A1L1QK30

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