Structure of PDB 5l3j Chain A

Receptor sequence
>5l3jA (length=360) Species: 562 (Escherichia coli) [Search protein sequence]
GLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKEIIVTIH
ADNSVSVQDDGRGIPTGIHPEEGVSAAEVIMTVLHVGVSVVNALSQKLEL
VIQREGKIHRQIYEHGVPQAPLAVTGETEKTGTMVRFWPSLETFTNVTEF
EYEILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHYEGGIKAFVEYLNKN
KTPIHPNIFYFSTEKDGIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHL
AGFRAAMTRTLNAYMDKEGYSKKAKVSATGDDAREGLIAVVSVKVPDPKF
SSQTKDKLVSSEVKSAVEQQMNELLAEYLLENPTDAKIVVGKIIDAARAR
EAARRAREMT
3D structure
PDB5l3j Discovery of Benzothiazole Scaffold-Based DNA Gyrase B Inhibitors.
ChainA
Resolution2.83 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6G9 A V43 N46 E50 V71 D73 R76 G77 I78 P79 V120 T165 V29 N32 E36 V57 D59 R62 G63 I64 P65 V88 T133 PDBbind-CN: -logKd/Ki=6.64,Kd=0.23uM
BindingDB: IC50=58nM,Kd=230nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:5l3j, PDBe:5l3j, PDBj:5l3j
PDBsum5l3j
PubMed27541007
UniProtP0AES6|GYRB_ECOLI DNA gyrase subunit B (Gene Name=gyrB)

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