Structure of PDB 5l2x Chain A

Receptor sequence
>5l2xA (length=271) Species: 9606 (Homo sapiens) [Search protein sequence]
MNRKWEAKLKQIEERASPEEPPSIWRLFHRQAQAFNFVKSCKEDVHVFAL
ECKVGDGQRIYLVTTYAEFWFYYKSRKNLLHCYEVIPENAVCKLYFDLEF
NKPANPGADGKKMVALLIEYVCKALQELYGVNCSAEDVLNLDSSTDEKFS
RHLIFQLHDVAFKDNIHVGNFLRKILQPALDLLPDLSFLVVKNNMGEKHL
FVDLGVYTRNRNFRLYKSSKIGKRVALEVTEDNKFFPIQSKDVSDEYQYF
LSSLVSNVRFSDTLRILTCEP
3D structure
PDB5l2x Structure and mechanism of human PrimPol, a DNA polymerase with primase activity.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.102: DNA primase AEP.
2.7.7.7: DNA-directed DNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A K10 H46 R47 Q48 D73 G74 Q75 R76 Y78 T285 R286 K10 H29 R30 Q31 D56 G57 Q58 R59 Y61 T208 R209
BS02 DTP A R76 Y100 D114 E116 K165 S167 H169 R288 N289 R291 K297 R59 Y83 D97 E99 K148 S150 H152 R211 N212 R214 K220
BS03 CA A D114 E116 D97 E99
Gene Ontology
Molecular Function
GO:0003887 DNA-directed DNA polymerase activity
GO:0003896 DNA primase activity
Biological Process
GO:0006269 DNA replication, synthesis of primer
GO:0042276 error-prone translesion synthesis

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Molecular Function
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Biological Process
External links
PDB RCSB:5l2x, PDBe:5l2x, PDBj:5l2x
PDBsum5l2x
PubMed27819052
UniProtQ96LW4|PRIPO_HUMAN DNA-directed primase/polymerase protein (Gene Name=PRIMPOL)

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