Structure of PDB 5l1p Chain A

Receptor sequence
>5l1pA (length=397) Species: 29301 (Streptomyces arenae) [Search protein sequence]
TDLPRLPFDNPDIMGIAPQMLALQKEGPIARVGTAGEDAWLVTRYDEVRT
LLADRRLRLSNPNPQPSAKSAARAFMVALMAGDDHETEPARHAQMRSLLI
PRFSTRRLRLMKTRIEHHVDELLDQLAASAPPVDLHRVLSFRLPTMVVCD
LLGVPLADRERFGQWARGTFDQSDNEHSANTFQQVVDYMLELVARKRVEP
GDDILSELIAEKDGALSDADIAHLGNAVLLFGYETTIVRIDLGTLLLLRN
PVQRAQLAEDPGLAPAAVEEILRLGVGGKGSNALIPRYAHGDITVGETVI
RTGDAVMLAIGAANYDDRAFPDGGLFDLTRVRPRSHLAFGHGARHCIGRT
LARIELTAVFERLFRRLPDLRLAVPEESLRWQEHRITGGFDEIPVTF
3D structure
PDB5l1p The Cytochrome P450-Catalyzed Oxidative Rearrangement in the Final Step of Pentalenolactone Biosynthesis: Substrate Structure Determines Mechanism.
ChainA
Resolution2.28 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D172 F232 E235 T236 T237 S282 C347 I348 G349 E356 T388
Catalytic site (residue number reindexed from 1) D171 F231 E234 T235 T236 S281 C346 I347 G348 E355 T387
Enzyme Commision number 1.14.19.8: pentalenolactone synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A M81 H93 R97 F104 G233 T236 R240 R288 A339 F340 R345 C347 G349 A353 M80 H92 R96 F103 G232 T235 R239 R287 A338 F339 R344 C346 G348 A352
BS02 7PT A R74 F232 T236 N283 I286 I387 R73 F231 T235 N282 I285 I386
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016636 oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0017000 antibiotic biosynthetic process
GO:1901780 pentalenolactone biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5l1p, PDBe:5l1p, PDBj:5l1p
PDBsum5l1p
PubMed27588339
UniProtE3VWI3|PNTM_STRAE Pentalenolactone synthase (Gene Name=pntM)

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