Structure of PDB 5l0u Chain A

Receptor sequence
>5l0uA (length=356) Species: 9606 (Homo sapiens) [Search protein sequence]
SKWKVFIDQINRSLENYEPCSSQNCSCYHGVIEEDLTPFRGGISRKMMAE
VVRRKLGTHYQITKNRLYRENDCMFPSRCSGVEHFILEVIGRLPDMEMVI
NVRDYPQVPKWMEPAIPVFSFSKTSEYHDIMYPAWTFWEGGPAVWPIYPT
GLGRWDLFREDLVRSAAQWPWKKKNSTAYFRGSRTSPERDPLILLSRKNP
KLVDAEYTKNQAWKSMKDTLGKPAAKDVHLVDHCKYKYLFNFRGVAASFR
FKHLFLCGSLVFHVGDEWLEFFYPQLKPWVHYIPVKTDLSNVQELLQFVK
ANDDVAQEIAERGSQFIRNHLQMDDITCYWENLLSEYSKFLSYNVTRRKG
YDQIIP
3D structure
PDB5l0u Structural basis of Notch O-glucosylation and O-xylosylation by mammalian protein-O-glucosyltransferase 1 (POGLUT1).
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.376: EGF-domain serine glucosyltransferase.
2.4.2.63: EGF-domain serine xylosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 660 A D133 I176 Y177 R210 G211 S212 R218 T237 D256 V257 G273 V274 A275 A276 S277 F278 R279 D104 I147 Y148 R181 G182 S183 R189 T208 D227 V228 G244 V245 A246 A247 S248 F249 R250
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity
GO:0035251 UDP-glucosyltransferase activity
GO:0035252 UDP-xylosyltransferase activity
GO:0046527 glucosyltransferase activity
GO:0140561 EGF-domain serine glucosyltransferase activity
GO:0140562 EGF-domain serine xylosyltransferase activity
Biological Process
GO:0001756 somitogenesis
GO:0006486 protein glycosylation
GO:0006493 protein O-linked glycosylation
GO:0007369 gastrulation
GO:0008593 regulation of Notch signaling pathway
GO:0010470 regulation of gastrulation
GO:0018242 protein O-linked glycosylation via serine
GO:0045747 positive regulation of Notch signaling pathway
GO:0048318 axial mesoderm development
GO:0048339 paraxial mesoderm development
GO:0060537 muscle tissue development
GO:0072359 circulatory system development
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0012505 endomembrane system

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5l0u, PDBe:5l0u, PDBj:5l0u
PDBsum5l0u
PubMed28775322
UniProtQ8NBL1|PGLT1_HUMAN Protein O-glucosyltransferase 1 (Gene Name=POGLUT1)

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