Structure of PDB 5kzn Chain A

Receptor sequence
>5kznA (length=503) Species: 9606 (Homo sapiens) [Search protein sequence]
KKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRI
NRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLPTAITGVIGGSY
SDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKA
MAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRA
MSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVAS
DGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPW
FREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHN
MHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFD
RFGDGIGRYNIFTYLRAGGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPL
PASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYW
PNA
3D structure
PDB5kzn Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A I72 D75 L78 L79 I50 D53 L56 L57
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5kzn, PDBe:5kzn, PDBj:5kzn
PDBsum5kzn
PubMed28002967
UniProtQ14416|GRM2_HUMAN Metabotropic glutamate receptor 2 (Gene Name=GRM2)

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