Structure of PDB 5kz8 Chain A

Receptor sequence
>5kz8A (length=302) Species: 9606 (Homo sapiens) [Search protein sequence]
PHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKL
FREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRM
KEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGCG
SPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRER
VLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDD
ELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLL
GY
3D structure
PDB5kz8 Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors.
ChainA
Resolution3.21 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D175 K177 E179 N180 D193 S212
Catalytic site (residue number reindexed from 1) D128 K130 E132 N133 D146 S151
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.26: [tau protein] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6Z5 A I59 V67 A80 K82 A132 G135 E136 L182 D193 I12 V20 A33 K35 A85 G88 E89 L135 D146
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5kz8, PDBe:5kz8, PDBj:5kz8
PDBsum5kz8
PubMed27816515
UniProtQ7KZI7|MARK2_HUMAN Serine/threonine-protein kinase MARK2 (Gene Name=MARK2)

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