Structure of PDB 5kyj Chain A

Receptor sequence
>5kyjA (length=251) Species: 9606 (Homo sapiens) [Search protein sequence]
VQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPASGSASQQR
FAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETA
RRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDD
AEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLR
FPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVKILHRLLQ
D
3D structure
PDB5kyj Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6Y8 A F271 L274 A275 M312 R319 F329 L330 H435 Q438 W457 F54 L57 A58 M95 R102 F112 L113 H218 Q221 W240 PDBbind-CN: -logKd/Ki=7.89,Ki=13nM
BindingDB: Ki=13nM,EC50=15nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006629 lipid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5kyj, PDBe:5kyj, PDBj:5kyj
PDBsum5kyj
PubMed27599745
UniProtP55055|NR1H2_HUMAN Oxysterols receptor LXR-beta (Gene Name=NR1H2)

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