Structure of PDB 5ky8 Chain A

Receptor sequence
>5ky8A (length=352) Species: 10090 (Mus musculus) [Search protein sequence]
SWDLAGYLLYCPCMGRFGNQADHFLGSLAFAKLLNRTLAVPPWIEYQHHK
PPFTNLHVSYQKYFKLEPLQAYHRVVSLEDFMENLAPSHWPPEKRVAYCF
EVAAQRSPDKKTCPMKEGNPFGPFWDQFHVSFNKSELFTGISFSASYKEQ
WTQRFPAKEHPVLALPGAPAQFPVLEEHRELQKYMVWSDEMVRTGEALIS
AHLVRPYVGIHLRIGSDWKNACAMLKDGTAGSHFMASPQCVGYSRSTATP
LTMTMCLPDLKEIQRAVTLWVRALNARSVYIATDSESYVSEIQQLFKDKV
RVVSLKPEVAQIDLYILGQADHFIGNCVSSFTAFVKRERDLHGRQSSFFG
MD
3D structure
PDB5ky8 Recognition of EGF-like domains by the Notch-modifying O-fucosyltransferase POFUT1.
ChainA
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.221: peptide-O-fucosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A R48 F49 G50 N51 H243 R245 A314 T315 D316 D345 S361 S362 F363 R16 F17 G18 N19 H211 R213 A282 T283 D284 D313 S329 S330 F331
Gene Ontology
Molecular Function
GO:0008417 fucosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0046922 peptide-O-fucosyltransferase activity
Biological Process
GO:0001525 angiogenesis
GO:0001756 somitogenesis
GO:0006004 fucose metabolic process
GO:0006486 protein glycosylation
GO:0006493 protein O-linked glycosylation
GO:0007219 Notch signaling pathway
GO:0007399 nervous system development
GO:0007507 heart development
GO:0008593 regulation of Notch signaling pathway
GO:0036066 protein O-linked fucosylation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5ky8, PDBe:5ky8, PDBj:5ky8
PDBsum5ky8
PubMed28530709
UniProtQ91ZW2|OFUT1_MOUSE GDP-fucose protein O-fucosyltransferase 1 (Gene Name=Pofut1)

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