Structure of PDB 5ky7 Chain A

Receptor sequence
>5ky7A (length=347) Species: 10090 (Mus musculus) [Search protein sequence]
SWDLAGYLLYCPCMGRFGNQADHFLGSLAFAKLLNRTLAVPPWIEYQHHK
PPFTNLHVSYQKYFKLEPLQAYHRVVSLEDFMENLAPSHWPPEKRVAYCF
EVAAQRTCPMKEGNPFGPFWDQFHVSFNKSELFTGISFSASYKEQWTQRF
PAKEHPVLALPGAPAQFPVLEEHRELQKYMVWSDEMVRTGEALISAHLVR
PYVGIHLRIGSDWKNACAMLKDGTAGSHFMASPQCVGYSRSTATPLTMTM
CLPDLKEIQRAVTLWVRALNARSVYIATDSESYVSEIQQLFKDKVRVVSL
KPEVAQIDLYILGQADHFIGNCVSSFTAFVKRERDLHGRQSSFFGMD
3D structure
PDB5ky7 Recognition of EGF-like domains by the Notch-modifying O-fucosyltransferase POFUT1.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.221: peptide-O-fucosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A R48 F49 G50 N51 H243 R245 W250 A314 T315 D316 D345 S361 S362 F363 R16 F17 G18 N19 H206 R208 W213 A277 T278 D279 D308 S324 S325 F326
BS02 BGC A V134 R138 V102 R106
Gene Ontology
Molecular Function
GO:0008417 fucosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0046922 peptide-O-fucosyltransferase activity
Biological Process
GO:0001525 angiogenesis
GO:0001756 somitogenesis
GO:0006004 fucose metabolic process
GO:0006486 protein glycosylation
GO:0006493 protein O-linked glycosylation
GO:0007219 Notch signaling pathway
GO:0007399 nervous system development
GO:0007507 heart development
GO:0008593 regulation of Notch signaling pathway
GO:0036066 protein O-linked fucosylation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5ky7, PDBe:5ky7, PDBj:5ky7
PDBsum5ky7
PubMed28530709
UniProtQ91ZW2|OFUT1_MOUSE GDP-fucose protein O-fucosyltransferase 1 (Gene Name=Pofut1)

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