Structure of PDB 5kxi Chain A

Receptor sequence
>5kxiA (length=363) Species: 9606 (Homo sapiens) [Search protein sequence]
AHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMM
TTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDF
AVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWT
YDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDI
TYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLL
SLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHR
SPRTHTMPTWVRRVFLDIVPRLLLERSVKEDWKYVAMVIDRIFLWMFIIV
CLLGTVGLFLPPW
3D structure
PDB5kxi X-ray structure of the human alpha 4 beta 2 nicotinic receptor.
ChainA
Resolution3.941 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NCT A Y100 W156 T157 Y204 Y93 W149 T150 Y197 PDBbind-CN: -logKd/Ki=7.74,Ki=18.2nM
BindingDB: Ki=2nM,IC50=430nM,EC50=2400nM
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0045211 postsynaptic membrane

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Cellular Component
External links
PDB RCSB:5kxi, PDBe:5kxi, PDBj:5kxi
PDBsum5kxi
PubMed27698419
UniProtP43681|ACHA4_HUMAN Neuronal acetylcholine receptor subunit alpha-4 (Gene Name=CHRNA4)

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