Structure of PDB 5kxa Chain A

Receptor sequence
>5kxaA (length=751) Species: 9606 (Homo sapiens) [Search protein sequence]
GSCKGRCFELQCRCDNLCKSYTSCCHDFDELCLKTARGWECTKDRCGEVR
NEENACHCSEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFV
RPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFP
NLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPLWI
TATKQGVKAGTFFWSVVIPHERRILTILQWLTLPDHERPSVYAFYSEQPD
FSGHKYGPFGPEMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDHGM
EDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFSNNAKYDPKAIIAAL
TCKKPDQHFKPYLKQHLPKRLHYANNRRIEDIHLLVERRWHVARKPFFQG
DHGFDNKVNSMQTVFVGYGSTFKYKTKVPPFENIELYNVMCDLLGLKPAP
NNGTHGSLNHLLRTNTFRPTMPEEVTRPNYPGIMYLQSDFDLGTEERHLL
YGRPAVLYRTRYDILYHTDFESGYSEIFLMPLWTSYTVSKQACVRPDVRV
SPSFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAF
KRVWNYFQRVLVKKYASERNGVNVISGPIFDYDYDGLHDTEDKIKQYVEG
SSIPVPTHYYSIITSCLDFTQPADKCDGPLSVSSFILPHRPDNEESCNSS
EDESKWVEELMKMHTARVRDIEHLTSLDFFRKTSRSYPEILTLKTYLHTY
E
3D structure
PDB5kxa Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis.
ChainA
Resolution2.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.39: alkylglycerophosphoethanolamine phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D312 H316 H475 D250 H254 H402
BS02 ZN A D172 T210 D359 H360 D110 T148 D297 H298
BS03 CA A D740 D742 D744 L746 H747 D748 D631 D633 D635 L637 H638 D639
BS04 6Y7 A L79 S82 F211 L214 Y215 K249 F250 H252 W255 W261 F275 W276 L17 S20 F149 L152 Y153 K187 F188 H190 W193 W199 F213 W214 BindingDB: IC50=<500nM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005044 scavenger receptor activity
GO:0016787 hydrolase activity
GO:0030247 polysaccharide binding
GO:0046872 metal ion binding
Biological Process
GO:0006955 immune response

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Molecular Function
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Biological Process
External links
PDB RCSB:5kxa, PDBe:5kxa, PDBj:5kxa
PDBsum5kxa
PubMed27754931
UniProtQ13822|ENPP2_HUMAN Autotaxin (Gene Name=ENPP2)

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