Structure of PDB 5ku9 Chain A

Receptor sequence
>5ku9A (length=149) Species: 9606,10090 [Search protein sequence]
DDLYRQSLEIISRYLREQATGSKKPLGEAGAAGRRALETLRRVGDGVQRN
HETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAF
VAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVE
3D structure
PDB5ku9 Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.11: exopolyphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6XJ A H224 A227 M231 H252 V253 D256 R263 T266 F270 H51 A54 M58 H79 V80 D83 R90 T93 F97 MOAD: ic50=1.49uM
PDBbind-CN: -logKd/Ki=5.83,IC50=1.49uM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:5ku9, PDBe:5ku9, PDBj:5ku9
PDBsum5ku9
PubMed28197319
UniProtP97287|MCL1_MOUSE Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Gene Name=Mcl1);
Q07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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