Structure of PDB 5ku3 Chain A

Receptor sequence
>5ku3A (length=126) Species: 9606 (Homo sapiens) [Search protein sequence]
STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTE
3D structure
PDB5ku3 Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.
ChainA
Resolution1.14 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6XH A W81 L92 Y139 I146 W40 L51 Y98 I105 PDBbind-CN: -logKd/Ki=4.89,IC50=13uM
BindingDB: IC50=10510nM
External links
PDB RCSB:5ku3, PDBe:5ku3, PDBj:5ku3
PDBsum5ku3
PubMed27682507
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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