Structure of PDB 5kty Chain A

Receptor sequence

>5ktyA (length=397) Species: 9606 (Homo sapiens) [Search protein sequence]

MKPACIKALTRIFKISDQDNDGTLNDAELNFFQRICFNTPLAPQALEDVK
NVVRKHISDGVADSGLTLKGFLFLHTLFIETTWTVLRRFGYDDDLDLTPE
YLFPLLKIPPDCTTELNHHAYLFLQSTFDKHDLDRDCALSPDELKDLFKV
FPYIPWGPDVNNTVCTNERGWITYQGFLSQWTLTTYLDVQRCLEYLGYLG
YSILTEQESQASAVTVTRDKKIDLQKKQTQRNVFRCNVIGVKNCGKSGVL
QALLGRNLMRQKKIREDHKSYYAINTVYVYGQEKYLLLHDISESEFLTEA
EIICDVVCLVYDVSNPKSFEYCARIFKQHFMDSRIPCLIVAAKSDLHEVK
QEYSISPTDFCRKHKMPPPQAFTCNTADAPSKDIFVKLTTMAMYPHV

3D structure

PDB

5kty Structural insights into Parkin substrate lysine targeting from minimal Miro substrates.

Chain

Resolution

2.522 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.6.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	GDP	A	N428 G430 K431 S432 G433 L443 K447 K528 D530 L531 T558 C559 N560	N243 G245 K246 S247 G248 L258 K262 K343 D345 L346 T373 C374 N375
BS02	GDP	A	K427 N428 K431 K454 D475 S477 E478	K242 N243 K246 K269 D290 S292 E293
BS03	CA	A	D197 D199 D201 T203 E208	D17 D19 D21 T23 E28
BS04	CA	A	D317 D319 D321 A323 E328	D132 D134 D136 A138 E143

Gene Ontology

	Molecular Function
GO:0003924	GTPase activity
GO:0005509	calcium ion binding
GO:0005525	GTP binding

View graph for
Molecular Function

External links

PDB	RCSB:5kty, PDBe:5kty, PDBj:5kty
PDBsum	5kty
PubMed	27605430
UniProt	Q8IXI2\|MIRO1_HUMAN Mitochondrial Rho GTPase 1 (Gene Name=RHOT1)

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