Structure of PDB 5ktx Chain A

Receptor sequence
>5ktxA (length=114) Species: 9606 (Homo sapiens) [Search protein sequence]
AAFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNP
MDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLA
EVFEQEIDPVMQAL
3D structure
PDB5ktx Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.
ChainA
Resolution1.27 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6XH A L1109 P1110 V1115 I1122 N1168 R1173 V1174 L27 P28 V33 I40 N86 R91 V92 PDBbind-CN: -logKd/Ki=7.70,IC50=0.02uM
BindingDB: IC50=20nM,EC50=1900nM
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5ktx, PDBe:5ktx, PDBj:5ktx
PDBsum5ktx
PubMed27682507
UniProtQ92793|CBP_HUMAN CREB-binding protein (Gene Name=CREBBP)

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