Structure of PDB 5ktu Chain A

Receptor sequence
>5ktuA (length=107) Species: 9606 (Homo sapiens) [Search protein sequence]
ELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTI
KRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQE
IDPVMQS
3D structure
PDB5ktu Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.
ChainA
Resolution1.38 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6XB A P1110 V1115 L1120 N1168 P22 V27 L32 N80 PDBbind-CN: -logKd/Ki=6.21,IC50=0.62uM
BindingDB: IC50=620nM
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:5ktu, PDBe:5ktu, PDBj:5ktu
PDBsum5ktu
PubMed27682507
UniProtQ92793|CBP_HUMAN CREB-binding protein (Gene Name=CREBBP)

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