Structure of PDB 5kt6 Chain A

Receptor sequence

>5kt6A (length=381) Species: 9606 (Homo sapiens)

SSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGV
KKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGF
DENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLV
GSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPES
CQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGI
SVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELL
ASLLNRVCQDGRKPHTVRLIIRRYSGRESRQCPIPSHVIQKLGYDVMTPM
VDILMKLFRNMVNVKMPFHLTLLSVCFCNLK

3D structure

• PDB: 5kt6 Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase iota.
• Chain: A
• Resolution: 3.54 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	Q84 K85 Y86 L124 Q325 S326 S328 E329 E330 S332	Q34 K35 Y36 L74 Q275 S276 S278 E279 E280 S282
BS02	dna	A	E152 K232 P265 G266 I267 G268 K270 T271 E383 S384 R385	E102 K182 P215 G216 I217 G218 K220 T221 E328 S329 R330
BS03	0KX	A	D59 L60 C62 F63 Y64 T90 Y93 R96 K102 D151	D9 L10 C12 F13 Y14 T40 Y43 R46 K52 D101
BS04	MG	A	D59 L60 D151	D9 L10 D101
BS05	MG	A	D59 D151 E152	D9 D101 E102

Gene Ontology

Molecular Function

• GO:0003684 damaged DNA binding
• GO:0003887 DNA-directed DNA polymerase activity

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:5kt6, PDBe:5kt6, PDBj:5kt6
• PDBsum: 5kt6
• PubMed: 27555320
• UniProt: Q9UNA4|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)