Structure of PDB 5kt5 Chain A

Receptor sequence

>5kt5A (length=379) Species: 9606 (Homo sapiens)

SSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEAGKLGV
KKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGF
DENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLV
GSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPES
CQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGI
SVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELL
ASLLNRVCQDGRKPHTVRLIIRRYSGRESRQCPIPSHVIQKLGYDVMTPM
VDILMKLFRNMVNVKFHLTLLSVCFCNLK

3D structure

• PDB: 5kt5 Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase iota.
• Chain: A
• Resolution: 2.798 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	Q84 K85 Y86 N105 R107 E122 L124 Q325 S326 S328 E330 S332	Q34 K35 Y36 N55 R57 E72 L74 Q275 S276 S278 E280 S282
BS02	dna	A	E152 K232 G266 I267 G268 K270 T271 E383 S384 R385 Q386	E102 K182 G216 I217 G218 K220 T221 E328 S329 R330 Q331
BS03	MN	A	D59 D151 E152	D9 D101 E102
BS04	0KX	A	D59 L60 C62 F63 Y64 V89 T90 K102 L103 D151	D9 L10 C12 F13 Y14 V39 T40 K52 L53 D101
BS05	MN	A	D59 L60 D151	D9 L10 D101

Gene Ontology

Molecular Function

• GO:0003684 damaged DNA binding
• GO:0003887 DNA-directed DNA polymerase activity

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:5kt5, PDBe:5kt5, PDBj:5kt5
• PDBsum: 5kt5
• PubMed: 27555320
• UniProt: Q9UNA4|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)