Structure of PDB 5kqs Chain A

Receptor sequence
>5kqsA (length=260) Species: 64320 (Zika virus) [Search protein sequence]
GETLGEKWKARLNQMSALEFYSYKKSGITEVCREEARRALKDATGGHAVS
RGSAKLRWLVERGYLQPYGKVIDLGCGRGGWSYYAATIRKVQEVKGYTKG
GPGHEEPMLVQSYGWNIVRLKSGVDVFHMAAEPCDTLLCDIGESSSSPEV
EEARTLRVLSMVGDWLEKRPGAFCIKVLCPYTSTMMETLERLQRRYGGGL
VRVPLSRNSTHEMYWVSGAKSNTIKSVSTTSQLLLGRMDGPRRPVKYEED
VNLGSGTRAV
3D structure
PDB5kqs Structures of NS5 Methyltransferase from Zika Virus.
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 M7G A K13 L16 N17 M19 F24 S150 S151 S152 R213 S215 K9 L12 N13 M15 F20 S144 S145 S146 R207 S209
BS02 SAM A S56 G81 G86 W87 T104 K105 V130 D131 V132 F133 D146 S50 G75 G80 W81 T98 K99 V124 D125 V126 F127 D140
Gene Ontology
Molecular Function
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5kqs, PDBe:5kqs, PDBj:5kqs
PDBsum5kqs
PubMed27633330
UniProtA0A024B7W1|POLG_ZIKVF Genome polyprotein

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