Structure of PDB 5kqd Chain A

Receptor sequence
>5kqdA (length=312) Species: 9606 (Homo sapiens) [Search protein sequence]
SPWFGMDIGGTLVKLSYFEPIEQEEVESLKSIRKYLTSNVAYRDVHLELK
DLTLFNLHFIRFPTQDLPTFIQMGGGAYKFEKLHKLDELDCLVKGLLYID
SVSFNGQAECYYFANCQKMPFNLDDPYPLLVVNIGSGVSILAVHSKDNYK
RVTGTSLGGGTFLGLCSLLTGCESFEEALEMASKGDSTQADKLVRDIYGG
DYERFGLPGWAVASSFGNMIYKEKRESVSKEDLARATLVTITNNIGSVAR
MCAVNEKINRVVFVGNFLRVNTLSMKLLAYALDYWSKGQLKALFLEHEGY
FGAVGALLGLPN
3D structure
PDB5kqd Allosteric Regulation of Mammalian Pantothenate Kinase.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.33: pantothenate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PKZ A G19 G20 L22 K24 G116 G191 S192 G193 V194 S195 R207 G210 T211 N322 G9 G10 L12 K14 G75 G135 S136 G137 V138 S139 R151 G154 T155 N266 PDBbind-CN: -logKd/Ki=6.30,IC50=0.5uM
Gene Ontology
Molecular Function
GO:0004594 pantothenate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0019842 vitamin binding
GO:0042803 protein homodimerization activity
GO:1905502 acetyl-CoA binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0015937 coenzyme A biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5kqd, PDBe:5kqd, PDBj:5kqd
PDBsum5kqd
PubMed27555321
UniProtQ9H999|PANK3_HUMAN Pantothenate kinase 3 (Gene Name=PANK3)

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