Structure of PDB 5kp8 Chain A

Receptor sequence
>5kp8A (length=410) Species: 489825 (Moorena producens 3L) [Search protein sequence]
QQVGIEALSVYGGAAQLELRKLAQARQLDISRFDNLMMKEKAVSLPYEDP
VSYAVNAAKPIIDRLSDADKQRIEMVITCSESGIDFGKSMSTYIQEYLGL
SRNCRMFELKQASYSGTAGLQMAINLILSQTFPGAKALVIATDISRFLVY
DWSFAEPSSGAGAVALLVSDTPHIFQIDVGCNGYYGYEVMDTCRPNPDSE
AGDADLSLLSYLDCCENAYRHYQNRVEGVDYRESFDYLSFHTPFGGMVKG
AHRNMMRRLKRAKPAEIEADFQRRVMPGLVYCQQVGNIMGATLFLSLAST
IDNGDFSTPRRIGMFSYGSGCCSEFYSGVVTPEGAAIAAQQGISAQLADR
YSLSMEEYEQLLYHSSAVAFGTRNVTLDYQLFPGVWKKIAGKGRLVLKAI
KEFHRKYEWV
3D structure
PDB5kp8 Anatomy of the beta-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.3.10: hydroxymethylglutaryl-CoA synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PNS A R33 F163 S167 S216 P252 F253 R32 F154 S158 S207 P243 F244
BS02 6VG A R33 E82 S114 F163 S167 H250 P252 F253 N296 S328 R32 E81 S113 F154 S158 H241 P243 F244 N287 S319
Gene Ontology
Molecular Function
GO:0004421 hydroxymethylglutaryl-CoA synthase activity
GO:0016746 acyltransferase activity
Biological Process
GO:0006084 acetyl-CoA metabolic process
GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:5kp8, PDBe:5kp8, PDBj:5kp8
PDBsum5kp8
PubMed27573844
UniProtF4Y432

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