Structure of PDB 5ko8 Chain A

Receptor sequence
>5ko8A (length=215) Species: 760192 (Haliscomenobacter hydrossis DSM 1100) [Search protein sequence]
AFIPYAGAQFEPEEMLSKSAEYYQFMDHRRTVREFSNRAIPLEVIENIVM
TASTAPSGAHKQPWTFVVVSDPQIKAKIRQAAEKEEFESYNGNEWLEDLQ
PFGTDWHKPFLEIAPYLIVVFRKAYDVLPDGTQRKNYYVQESVGIACGFL
LAAIHQAGLVALTHTPSPMNFLQKILQRPENERPFLLVPVGYPAEGAMVP
DLQRKDKAAVMVVYH
3D structure
PDB5ko8 Active Site Binding Is Not Sufficient for Reductive Deiodination by Iodotyrosine Deiodinase.
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.21.1.1: iodotyrosine deiodinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMN A R34 R35 T36 R38 F110 L170 T171 H172 T173 R29 R30 T31 R33 F102 L162 T163 H164 T165
BS02 IYR A E91 Y95 L107 T112 K116 E86 Y90 L99 T104 K108 MOAD: Kd=8.2uM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0140616 iodotyrosine deiodinase activity

View graph for
Molecular Function
External links
PDB RCSB:5ko8, PDBe:5ko8, PDBj:5ko8
PDBsum5ko8
PubMed28157283
UniProtF4KU78|IYD_HALH1 Iodotyrosine deiodinase (Gene Name=IYD)

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