Structure of PDB 5ko1 Chain A

Receptor sequence
>5ko1A (length=265) Species: 9606 (Homo sapiens) [Search protein sequence]
QIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSIA
IVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTL
RELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQ
GYQVKLAGFELRKDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEI
ATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSV
RPSVDEILKKLSTFS
3D structure
PDB5ko1 ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis.
ChainA
Resolution2.16 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K331 S335 N336 G349
Catalytic site (residue number reindexed from 1) K140 S144 N145 G158
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6UY A R210 E211 N212 S215 L217 A228 K230 E250 M283 C286 L338 A348 G349 R19 E20 N21 S24 L26 A37 K39 E59 M92 C95 L147 A157 G158 MOAD: Kd=230nM
PDBbind-CN: -logKd/Ki=6.64,Kd=230nM
BindingDB: Kd=230nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5ko1, PDBe:5ko1, PDBj:5ko1
PDBsum5ko1
PubMed27832137
UniProtQ8NB16|MLKL_HUMAN Mixed lineage kinase domain-like protein (Gene Name=MLKL)

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