Structure of PDB 5knq Chain A

Receptor sequence
>5knqA (length=186) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
ELYPGDIKSVLLTAEQIQARIAELGEQIGNDYRELSATTGQDLLLITVLK
GAVLFVTDLARAIPVPTQFEFMAVSSYGSSTSSSGVVRILKDLDRDIHGR
DVLIVEDVVDSGLTLSWLSRNLTSRNPRSLRVCTLLRKPDAVHANVEIAY
VGFDIPNDFVVGYGLDYDERYRDLSYIGTLDPRVYQ
3D structure
PDB5knq Crystal structure of Mycobacterium tuberculosis hypoxanthine guanine phosphoribosyltransferase in complex with pyrrolidine nucleoside phosphonate
ChainA
Resolution2.553 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E122 D123 D126 F175 R188
Catalytic site (residue number reindexed from 1) E106 D107 D110 F159 R172
Enzyme Commision number 2.4.2.8: hypoxanthine phosphoribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6W8 A D126 S127 G128 K154 F175 V176 L181 D182 D110 S111 G112 K138 F159 V160 L165 D166 BindingDB: Ki=8000nM
BS02 MG A E122 D123 E106 D107
BS03 POP A K66 G67 R188 K50 G51 R172
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004422 hypoxanthine phosphoribosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
GO:0052657 guanine phosphoribosyltransferase activity
Biological Process
GO:0006166 purine ribonucleoside salvage
GO:0006177 GMP biosynthetic process
GO:0006178 guanine salvage
GO:0006188 IMP biosynthetic process
GO:0032263 GMP salvage
GO:0032264 IMP salvage
GO:0043101 purine-containing compound salvage
GO:0046100 hypoxanthine metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5knq, PDBe:5knq, PDBj:5knq
PDBsum5knq
PubMed
UniProtP9WHQ9|HGPRT_MYCTU Hypoxanthine-guanine phosphoribosyltransferase (Gene Name=hpt)

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