Structure of PDB 5knj Chain A

Receptor sequence
>5knjA (length=252) Species: 9606 (Homo sapiens) [Search protein sequence]
IKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKAIVRQTFN
KEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDRE
KDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLA
GFDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCN
SEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKL
ST
3D structure
PDB5knj ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis.
ChainA
Resolution2.88 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K331 S335 N336 G349
Catalytic site (residue number reindexed from 1) K133 S137 N138 G151
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6UX A L217 E250 M254 L263 M283 Y285 C286 G289 E293 L338 A348 G349 L25 E52 M56 L65 M85 Y87 C88 G91 E95 L140 A150 G151 PDBbind-CN: -logKd/Ki=6.94,Kd=116nM
BindingDB: Kd=9300nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5knj, PDBe:5knj, PDBj:5knj
PDBsum5knj
PubMed27832137
UniProtQ8NB16|MLKL_HUMAN Mixed lineage kinase domain-like protein (Gene Name=MLKL)

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