Structure of PDB 5kmi Chain A

Receptor sequence
>5kmiA (length=300) Species: 9606 (Homo sapiens) [Search protein sequence]
LQGHIIENPQCVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKML
VAVKALKESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMR
HGDLNRFLRSHGPDAKLGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHF
VHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPP
ESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGREL
ERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG
3D structure
PDB5kmi Structural characterization of nonactive site, TrkA-selective kinase inhibitors.
ChainA
Resolution1.87 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D650 A652 R654 N655 D668 S677 L689
Catalytic site (residue number reindexed from 1) D154 A156 R158 N159 D172 S181 L193
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6UE A G488 H489 I490 F521 K544 E560 L564 M587 H648 G667 D668 G670 G3 H4 I5 F31 K54 E67 L71 M94 H152 G171 D172 G174 BindingDB: IC50=99nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5kmi, PDBe:5kmi, PDBj:5kmi
PDBsum5kmi
PubMed28039433
UniProtP04629|NTRK1_HUMAN High affinity nerve growth factor receptor (Gene Name=NTRK1)

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