Structure of PDB 5kla Chain A

Receptor sequence

>5klaA (length=337) Species: 7227 (Drosophila melanogaster) [Search protein sequence]

SGRSRLLEDFRNQRYPNLQLRDLANHIVEFSQDQHGSRFIQQKLERATAA
EKQMVFSEILAAAYSLMTDVFGNYVIQKFFEFGTPEQKNTLGMQVKGHVL
QLALQMYGCRVIQKALESISPEQQQEIVHELDGHVLKCVKDQNGNHVVQK
CIECVDPVALQFIINAFKGQVYSLSTHPYGCRVIQRILEHCTAEQTTPIL
DELHEHTEQLIQDQYGNYVIQHVLEHGKQEDKSILINSVRGKVLVLSQHK
FASNVVEKCVTHATRGERTGLIDEVCTFNDNALHVMMKDQYANYVVQKMI
DVSEPTQLKKLMTKIRPHMAALRKYTYGKHINAKLEK

3D structure

PDB

5kla Drosophila Nanos acts as a molecular clamp that modulates the RNA-binding and repression activities of Pumilio.

Chain

Resolution

1.14 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	Q1123 R1127 Q1130 F1160 N1162 Y1163 Y1196 R1199 Q1202 H1235 C1270 R1271 Q1274 Y1304 N1306 Y1307 Q1310 K1339 S1342 N1343 E1346 N1382 Y1383 Q1386 Y1416 H1419	Q34 R38 Q41 F71 N73 Y74 Y107 R110 Q113 H146 C181 R182 Q185 Y215 N217 Y218 Q221 K250 S253 N254 E257 N293 Y294 Q297 Y327 H330	PDBbind-CN: Kd=26.3nM

Gene Ontology

	Molecular Function
GO:0003723	RNA binding

View graph for
Molecular Function

External links

PDB	RCSB:5kla, PDBe:5kla, PDBj:5kla
PDBsum	5kla
PubMed	27482653
UniProt	P25822\|PUM_DROME Maternal protein pumilio (Gene Name=pum)

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