Structure of PDB 5kl8 Chain A

Receptor sequence
>5kl8A (length=309) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
RSRLLEDFRNQQDQHGSRFIQQKLERATAAEKQMVFSEILAAAYSLMTDV
FGNYVIQKFFEFGTPEQKNTLGMQVKGHVLQLALQMYGCRVIQKALESIS
PEQQQEIVHELDGHVLKCVKDQNGNHVVQKCIECVDPVALQFIINAFKGQ
VYSLSTHPYGCRVIQRILEHCTAEQTTPILDELHEHTEQLIQDQYGNYVI
QHVLEHGKQEDKSILINSVRGKVLVLSQHKFASNVVEKCVTHATRGERTG
LIDEVCTFNDNALHVMMKDQYANYVVQKMIDVSEPTQLKKLMTKIRPHMA
ALRKYTYGK
3D structure
PDB5kl8 Drosophila Nanos acts as a molecular clamp that modulates the RNA-binding and repression activities of Pumilio.
ChainA
Resolution4.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A N1162 Y1163 M1195 Y1196 R1199 Q1231 H1235 Y1268 R1271 Q1274 N1306 Y1307 Q1310 S1342 N1343 E1346 N1382 Y1383 Q1386 K1413 Y1414 T1415 Y1416 N53 Y54 M86 Y87 R90 Q122 H126 Y159 R162 Q165 N197 Y198 Q201 S233 N234 E237 N273 Y274 Q277 K304 Y305 T306 Y307 PDBbind-CN: Kd=12nM
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:5kl8, PDBe:5kl8, PDBj:5kl8
PDBsum5kl8
PubMed27482653
UniProtP25822|PUM_DROME Maternal protein pumilio (Gene Name=pum)

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