Structure of PDB 5kl7 Chain A

Receptor sequence

>5kl7A (length=87) Species: 9606 (Homo sapiens)

EKPYQCDFKDCERRFSRSDRLKRHQRRHTGVKPFQCKTCQRKFSRSDHLK
THTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQ

3D structure

• PDB: 5kl7 Denys-Drash syndrome associated WT1 glutamine 369 mutants have altered sequence-preferences and altered responses to epigenetic modifications.
• Chain: A
• Resolution: 1.579 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	R362 R366 R369 R372 H373 R376 R390 R394 H397 H401 T404 R424 R430	R13 R17 R20 R23 H24 R27 R41 R45 H48 H52 T55 R75 R81
BS02	dna	A	R366 D368 K399 S425 D426	R17 D19 K50 S76 D77
BS03	ZN	A	C355 C360 H373 H377	C6 C11 H24 H28
BS04	ZN	A	C385 C388 H401 H405	C36 C39 H52 H56
BS05	ZN	A	C413 C418 H431 H435	C64 C69 H82 H86

External links

• PDB: RCSB:5kl7, PDBe:5kl7, PDBj:5kl7
• PDBsum: 5kl7
• PubMed: 27596598
• UniProt: P19544|WT1_HUMAN Wilms tumor protein (Gene Name=WT1)