Structure of PDB 5kl4 Chain A

Receptor sequence

>5kl4A (length=90) Species: 9606 (Homo sapiens) [Search protein sequence]

GSEKPYQCDFKDCERRFSRSDHLKRHQRRHTGVKPFQCKTCQRKFSRSDH
LKTHTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQR

3D structure

PDB

5kl4 Denys-Drash syndrome associated WT1 glutamine 369 mutants have altered sequence-preferences and altered responses to epigenetic modifications.

Chain

Resolution

1.783 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	R366 H369 R372 H373 R376 R390 R394 H397 H401 T404 R424 R430	R19 H22 R25 H26 R29 R43 R47 H50 H54 T57 R77 R83
BS02	dna	A	R366 K399 S425 D426	R19 K52 S78 D79
BS03	ZN	A	C355 C360 H373 H377	C8 C13 H26 H30
BS04	ZN	A	C385 C388 H401 H405	C38 C41 H54 H58
BS05	ZN	A	C413 C418 H431 H435	C66 C71 H84 H88
BS06	CA	A	C355 C360	C8 C13

External links

PDB	RCSB:5kl4, PDBe:5kl4, PDBj:5kl4
PDBsum	5kl4
PubMed	27596598
UniProt	P19544\|WT1_HUMAN Wilms tumor protein (Gene Name=WT1)