Structure of PDB 5kkq Chain A

Receptor sequence

>5kkqA (length=147) Species: 9606 (Homo sapiens) [Search protein sequence]

PLGSPHKCPDCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKL
KRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHSGEKPYECYICHARF
TQSGTMKMHILQKHTENVAKFHCPHCDTVIARKSDLGVHLRKQHSYI

3D structure

PDB

5kkq Structural Basis for the Versatile and Methylation-Dependent Binding of CTCF to DNA.

Chain

Resolution

1.744 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	F351 K367 Y392 K395 Y407 S419 K423 S450	F35 K51 Y76 K79 Y91 S103 K107 S134	PDBbind-CN: Kd=9nM
BS02	dna	A	F331 E336 R339 H340 Y343 K344 Y358 E362 K365 R368 H369 S372 R377 Y386 R389 K393 R396 H397 T400 K405 F416 T417 Q418 T421 H425 K429 I446 A447 R448 D451	F15 E20 R23 H24 Y27 K28 Y42 E46 K49 R52 H53 S56 R61 Y70 R73 K77 R80 H81 T84 K89 F100 T101 Q102 T105 H109 K113 I130 A131 R132 D135	PDBbind-CN: Kd=9nM
BS03	ZN	A	C324 C327 H340 H345	C8 C11 H24 H29
BS04	ZN	A	C353 C356 H369 H373	C37 C40 H53 H57
BS05	ZN	A	C381 C384 H397 H401	C65 C68 H81 H85
BS06	ZN	A	C409 C412 H425 H430	C93 C96 H109 H114
BS07	ZN	A	C439 C442 H455 H460	C123 C126 H139 H144

External links

PDB	RCSB:5kkq, PDBe:5kkq, PDBj:5kkq
PDBsum	5kkq
PubMed	28529057
UniProt	P49711\|CTCF_HUMAN Transcriptional repressor CTCF (Gene Name=CTCF)