Structure of PDB 5kj0 Chain A

Receptor sequence
>5kj0A (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB5kj0 Assessment of Bromodomain Target Engagement by a Series of BI2536 Analogues with Miniaturized BET-BRET.
ChainA
Resolution1.51 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 6TB A W81 P82 Q85 V87 L92 Y97 Y139 N140 I146 W40 P41 Q44 V46 L51 Y56 Y98 N99 I105 MOAD: ic50=130nM
PDBbind-CN: -logKd/Ki=6.89,IC50=130nM
BindingDB: IC50=100nM
External links
PDB RCSB:5kj0, PDBe:5kj0, PDBj:5kj0
PDBsum5kj0
PubMed27862999
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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