Structure of PDB 5khx Chain A

Receptor sequence
>5khxA (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]
PTHFEKRFLKRIRDLGKVELCRYDPEGDNTGEQVAVKSLKNHIADLKKEI
EILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKIN
LKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTK
AIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLT
YCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQ
LMRKCWEFQPSNRTSFQNLIEGFEALLK
3D structure
PDB5khx Development of a high-throughput crystal structure-determination platform for JAK1 using a novel metal-chelator soaking system.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1003 A1005 R1007 N1008 D1021 D1040
Catalytic site (residue number reindexed from 1) D127 A129 R131 N132 D145 D164
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6TE A G882 A906 E957 F958 L959 N1008 L1010 D1021 G16 A35 E81 F82 L83 N132 L134 D145 PDBbind-CN: -logKd/Ki=7.85,IC50=14nM
BindingDB: IC50=90nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5khx, PDBe:5khx, PDBj:5khx
PDBsum5khx
PubMed27827355
UniProtP23458|JAK1_HUMAN Tyrosine-protein kinase JAK1 (Gene Name=JAK1)

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