Structure of PDB 5khk Chain A

Receptor sequence
>5khkA (length=201) Species: 10090 (Mus musculus) [Search protein sequence]
DSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSIL
GELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGD
YIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEICLLTRGRRT
ASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSI
L
3D structure
PDB5khk Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening.
ChainA
Resolution2.07 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6SZ A V564 M572 F580 G581 E582 I583 C584 R591 T592 A593 R632 I636 V122 M130 F138 G139 E140 I141 C142 R149 T150 A151 R190 I194 MOAD: Kd=0.41uM
PDBbind-CN: -logKd/Ki=6.39,Kd=0.41uM
External links
PDB RCSB:5khk, PDBe:5khk, PDBj:5khk
PDBsum5khk
PubMed27568927
UniProtO88703|HCN2_MOUSE Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Gene Name=Hcn2)

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