Structure of PDB 5khg Chain A

Receptor sequence
>5khgA (length=201) Species: 10090 (Mus musculus) [Search protein sequence]
DSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSIL
GELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGD
YIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEICLLTRGRRT
ASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSI
L
3D structure
PDB5khg Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening.
ChainA
Resolution2.241 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CC7 A V564 F580 G581 E582 I583 C584 R591 T592 R632 V122 F138 G139 E140 I141 C142 R149 T150 R190 MOAD: Kd=20.23uM
PDBbind-CN: -logKd/Ki=4.69,Kd=20.23uM
External links
PDB RCSB:5khg, PDBe:5khg, PDBj:5khg
PDBsum5khg
PubMed27568927
UniProtO88703|HCN2_MOUSE Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Gene Name=Hcn2)

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