Structure of PDB 5kh9 Chain A

Receptor sequence
>5kh9A (length=100) Species: 9606 (Homo sapiens) [Search protein sequence]
PLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQENWVCLSCYQVYCGRYIN
GHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKNIAHQNKFG
3D structure
PDB5kh9 Small Molecule Antagonists of the Interaction between the Histone Deacetylase 6 Zinc-Finger Domain and Ubiquitin.
ChainA
Resolution1.07 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.-
3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1145 H1164 H1170 C37 H56 H62
BS02 ZN A C1133 C1136 C1153 H1160 C25 C28 C45 H52
BS03 ZN A C1113 H1115 C1183 C1186 C5 H7 C75 C78
BS04 6T5 A W1143 R1155 W1182 Y1189 W35 R47 W74 Y81
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:5kh9, PDBe:5kh9, PDBj:5kh9
PDBsum5kh9
PubMed29019676
UniProtQ9UBN7|HDAC6_HUMAN Histone deacetylase 6 (Gene Name=HDAC6)

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