Structure of PDB 5kh3 Chain A

Receptor sequence
>5kh3A (length=101) Species: 9606 (Homo sapiens) [Search protein sequence]
SPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQENWVCLSCYQVYCGRYI
NGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKNIAHQNKF
G
3D structure
PDB5kh3 Small Molecule Antagonists of the Interaction between the Histone Deacetylase 6 Zinc-Finger Domain and Ubiquitin.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.-
3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1145 C1148 H1164 H1170 C38 C41 H57 H63
BS02 ZN A C1133 C1136 C1153 H1160 C26 C29 C46 H53
BS03 ZN A C1113 H1115 C1183 C1186 C6 H8 C76 C79
BS04 6U6 A W1143 G1154 R1155 W1182 Y1184 Y1189 W36 G47 R48 W75 Y77 Y82 PDBbind-CN: -logKd/Ki=4.22,Kd=60uM
BindingDB: IC50=55000nM,Kd=60000nM
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:5kh3, PDBe:5kh3, PDBj:5kh3
PDBsum5kh3
PubMed29019676
UniProtQ9UBN7|HDAC6_HUMAN Histone deacetylase 6 (Gene Name=HDAC6)

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