Structure of PDB 5kdr Chain A

Receptor sequence
>5kdrA (length=301) Species: 367830 (Staphylococcus aureus subsp. aureus USA300) [Search protein sequence]
LDFEKPLFEIRNKIESQEEIDMLEASLERETKKIYTNLKPWDRVQIARLQ
ERPTTLDYIPYIFDSFMELHGDRNFRDDPAMIGGIGFLNGRAVTVIGQQR
GKDTKDNIYRNFGMAHPEGYRKALRLMKQAEKFNRPIFTFIDTKGAYPGK
AAEERGQSESIATNLIEMASLKVPVIAIVIGEGGSGGALGIGIANKVLML
ENSTYSVISPEGAAALLWKDSNLAKIAAETMKITAHDIKQLGIIDDVISE
PLGGAHKDIEQQALAIKSAFVAQLDSLESLSRDEIANDRFEKFRNIGSYI
E
3D structure
PDB5kdr Crystal Structure of Carboxyltransferase from Staphylococcus aureus Bound to the Antibacterial Agent Moiramide B.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.3.15: acetyl-CoA carboxytransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YT5 A S198 L229 S185 L216 PDBbind-CN: -logKd/Ki=8.30,Ki=5nM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003989 acetyl-CoA carboxylase activity
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0016743 carboxyl- or carbamoyltransferase activity
GO:0016874 ligase activity
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:2001295 malonyl-CoA biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0009317 acetyl-CoA carboxylase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5kdr, PDBe:5kdr, PDBj:5kdr
PDBsum5kdr
PubMed27471863
UniProtQ2FXM7|ACCA_STAA8 Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (Gene Name=accA)

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