Structure of PDB 5kcu Chain A

Receptor sequence
>5kcuA (length=226) Species: 9606 (Homo sapiens) [Search protein sequence]
LALSLTADQMVSALLDAEPPILYSEYPFSEASMMGLLTNLADRELVHMIN
WAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLL
LDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVY
TFKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSN
KGMEHLYSMKCKNLSDLLLEMLDAHR
3D structure
PDB5kcu Full antagonism of the estrogen receptor without a prototypical ligand side chain.
ChainA
Resolution2.03 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 K362 L372 V376 E380 L539 E542 I49 K53 L63 V67 E71 L217 E220
BS02 OB8 A T347 E353 M388 L391 E419 G420 M421 I424 G521 H524 L525 M528 T38 E44 M79 L82 E110 G111 M112 I115 G202 H205 L206 M209 MOAD: ic50=6.49uM
External links
PDB RCSB:5kcu, PDBe:5kcu, PDBj:5kcu
PDBsum5kcu
PubMed27870835
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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