Structure of PDB 5kct Chain A

Receptor sequence
>5kctA (length=236) Species: 9606 (Homo sapiens) [Search protein sequence]
KNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADR
ELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKL
LFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSII
LLNSGVYTFKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILS
HIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR
3D structure
PDB5kct Full antagonism of the estrogen receptor without a prototypical ligand side chain.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 K362 L372 H373 Q375 V376 E380 D538 L539 E542 I56 K60 L70 H71 Q73 V74 E78 D226 L227 E230
BS02 OB7 A M343 L346 T347 A350 E353 M388 F404 G420 M421 I424 F425 L428 H524 L525 L540 M41 L44 T45 A48 E51 M86 F102 G118 M119 I122 F123 L126 H212 L213 L228 MOAD: ic50=0.43uM
External links
PDB RCSB:5kct, PDBe:5kct, PDBj:5kct
PDBsum5kct
PubMed27870835
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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