Structure of PDB 5kcf Chain A

Receptor sequence
>5kcfA (length=236) Species: 9606 (Homo sapiens) [Search protein sequence]
KNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADR
ELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKL
LFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSII
LLNSGVYTKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSH
IRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRL
3D structure
PDB5kcf Full antagonism of the estrogen receptor without a prototypical ligand side chain.
ChainA
Resolution2.07 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 K362 L372 H373 Q375 V376 E380 D538 L539 E542 I56 K60 L70 H71 Q73 V74 E78 D225 L226 E229
BS02 OB5 A L346 T347 A350 E353 M388 F404 M421 I424 F425 L428 L525 L44 T45 A48 E51 M86 F102 M119 I122 F123 L126 L212 MOAD: ic50=0.72uM
External links
PDB RCSB:5kcf, PDBe:5kcf, PDBj:5kcf
PDBsum5kcf
PubMed27870835
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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