Structure of PDB 5kce Chain A

Receptor sequence
>5kceA (length=223) Species: 9606 (Homo sapiens) [Search protein sequence]
KNSLALSLTADQMVSALLDAEPPILYSEYSMMGLLTNLADRELVHMINWA
KRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLD
RNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGDHIH
RVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLY
SMKCKNVVPLSDLLLEMLDAHRL
3D structure
PDB5kce Full antagonism of the estrogen receptor without a prototypical ligand side chain.
ChainA
Resolution1.847 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 K362 L539 E542 M543 I47 K51 L213 E216 M217
BS02 OB3 A M343 T347 E353 L387 L391 F404 G420 M421 G521 H524 L525 M528 M32 T36 E42 L76 L80 F93 G109 M110 G195 H198 L199 M202 MOAD: ic50=0.45uM
BS03 OB3 A M343 T347 E353 L387 L391 F404 G420 G521 H524 M528 M32 T36 E42 L76 L80 F93 G109 G195 H198 M202 MOAD: ic50=0.45uM
External links
PDB RCSB:5kce, PDBe:5kce, PDBj:5kce
PDBsum5kce
PubMed27870835
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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