Structure of PDB 5kcc Chain A

Receptor sequence
>5kccA (length=237) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILL
NSGVYTSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLIL
SHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR
3D structure
PDB5kcc Full antagonism of the estrogen receptor without a prototypical ligand side chain.
ChainA
Resolution2.386 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 K362 L372 V376 L379 D538 L539 E542 I54 K58 L68 V72 L75 D227 L228 E231
BS02 OB1 A M343 L346 T347 E353 M388 L391 F404 M421 I424 G521 H524 L525 M39 L42 T43 E49 M84 L87 F100 M117 I120 G210 H213 L214
External links
PDB RCSB:5kcc, PDBe:5kcc, PDBj:5kcc
PDBsum5kcc
PubMed27870835
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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